Category

Description

Company Summary

Ring Therapeutics Inc. is a privately held, early-stage biotechnology company pioneering a completely novel form of gene therapy by exploiting a family of naturally occurring commensal viruses to create the first redosable and targetable DNA medicines. This approach enables a powerful new class of tropic, persistent, non-integrating vectors that overcome the immunogenicity, and limited tropism of existing gene therapy vectors. Ring Therapeutics is leveraging this versatile technology to develop a broad pipeline of novel, targeted medicines for disease with high unmet medical need.

Ring Therapeutics was founded by Flagship Pioneering, focused on launching breakthrough companies based on internally conceived innovations and insights. Flagship Pioneering has created over 40 groundbreaking companies over the past fifteen years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Seres Therapeutics (NASDAQ:MCRB), Moderna, Syros Pharmaceuticals (SYRS), Rubius Therapeutics, Axcella Health, Evelo Biosciences, and Indigo Agriculture.

Position Summary

Ring is seeking a Scientist to join the team to advance the science of pioneering novel insights into commensal viruses to develop therapeutic hypotheses from technology validation to target discovery and beyond. The successful candidate will join the Bioprocess Development Group dedicated to early stage development of viral therapeutics and contribute to ongoing efforts to develop production platforms using molecular biology and cellular engineering techniques.

A background in virology, viral production and knowledge of the molecular components involved with virus production will be highly valued. Candidates with experience and training in synthetic virology, genetic engineering, viral design, or high-throughput techniques will be preferred. The scientist candidate must be independent and goal oriented, and able to efficiently lead teams and complete multiple projects in parallel. The position will require creativity, resourcefulness, and adaptability. We are searching for enthusiastic, innovative, and highly motivated individuals who are comfortable working in a fast-paced entrepreneurial environment.

Responsibilities

• Assume responsibility for developing and validating bioanalytical methods to support preclinical and clinical development of novel gene therapy programs. Assays to be developed include (but are not limited to) transduction, qPCR/dd PCR, HCP and DNA assays in addition to other Biophysical, biochemical and Cell based assays.
• Work closely with research team to transfer assays to process development group for qualification and validation
• Lead strategy and initiatives for analytical team, support in-process assays for process and formulation development
• Author, review and finalize validation reports, IND sections and responses to regulatory agency questions regarding bioanalytical methods and sample analysis
• Effectively collaborate with a fully integrated process development and other teams
• Additional duties and responsibilities as required

Qualifications

• M.S., PhD or equivalent in a relevant biological discipline and at least 1-3 years of relevant pharmaceutical industry experience
• Deep knowledge of bioanalytical assay development, qualification and validation requirements to comply with current regulatory standards
• Proficient in relevant analytical methodology, emerging new technologies, troubleshooting and problem solving
• Working knowledge of Good Laboratory Practices (GLP)
• Familiarity with formulation development for Biologics or, gene therapy development
• Excellent communication skills and proven ability to work effectively as a member of a multidisciplinary team
• Demonstrated capacity to work in a fast-paced environment

Recruitment